A group of scientists on the Indian Institute of Science Education and Research (IISER) Bhopal have in a evaluate recognized the biomolecular relationships between Covid-19, ageing, and diabetes. The evaluate, revealed within the journal Molecular and Cellular Biochemistry, offered that present medicine used to treat diabetes, weight problems and ageing can probably be used to treat Covid-19. Similar naturally present biomolecules had been additionally explored together for the Covid remedy.
“There are classes of compounds such as polyphenols found in plant-based food, curcumin (found in turmeric), and resveratrol (found in grapes), have been shown to not only slow down the ageing process, but also possess anti-viral properties,” stated Dr. Amjad Husain, Principal Scientist, and CEO of Innovation and Incubation Center for Entrepreneurship (IICE), IISER Bhopal, in a press release.
Some different polyphenols that the researchers have recognized as being helpful for each Covid-19 remedy and comorbidity circumstances akin to diabetes and ageing might embrace catechins (current in green tea, cocoa and berries), procyanidins (present in apples, cinnamon and grape pores and skin), and theaflavin (present in black tea).
The researchers additionally current proof of some present potential anti-ageing medicine akin to Rapamycin that can be explored for the Covid-19 remedy due to the widespread biochemical pathways related to these ailments. Another such instance is a drug Metformin , which is often used to regulate blood sugar.
The evaluate confirmed that on the molecular degree, there are intersecting pathways which can be widespread to diabetes, ageing, and Covid-19. All three circumstances are related to oxidative stress and decreasing of the immune response and problems arising from them result in the onset of quite a few different ailments akin to cardiovascular problems, eye ailments, neuropathy (nerve ailments), and nephropathy (kidney issues).
The researchers imagine that a super therapeutic candidate for Covid-19 ought to be capable to goal the pathways which can be widespread to diabetes, ageing and the SARS-CoV-2 an infection.
Further, computational research confirmed that lipids current in cell membranes play an vital function in coronavirus infectivity.
Natural compounds akin to polyphenols might have an effect on the binding of the virus to host receptors and the molecular interactions required for virus replication and launch, thereby stopping the an infection in its early phases, the group defined.